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Neonatal and Developmental
Biology Training Fellowship Program
 Preceptor
Research Interests | Requirements | Application
Instructions
The aim of the Training Program in Developmental and Neonatal Biology
is to provide educational opportunities for young people to achieve excellence
in clinical newborn medicine, scholarly basic science and clinical research,
and medical education. The Program is designed to encourage the cross-fertilization
of ideas that will enrich the research of the basic, laboratory-based
and the clinically-oriented scientist. For those trainees interested
in clinical training, the Program offers intensive clinical experiences
with newborns, including the opportunity for clinical investigation,
as well as the opportunity for advanced study in developmental biology,
especially at the cellular and molecular level. For those trainees interested
in the basic sciences, the Program offers exposure to clinical problems
that stimulate curiosity in human development and enhance the translation
of bench research discoveries to bedside clinical solutions. The objective
of this combined Training Program is to build bridges between investigators
in basic science departments and physicians in clinical departments,
sharing as a common goal an in-depth understanding of the development
of organ systems. Predoctoral trainees receive their degrees from one
of the six Ph.D. granting academic units (the Departments of Biological
Sciences, Developmental Biology, Genetics, Molecular and Cellular Physiology,
Molecular Pharmacology, and Neurobiology) as well as from the Combined
Admissions Mode in the Medical School. Trainees for this component of
the Program are selected by the Predoctoral Committee. Postdoctoral trainees
have completed a Ph.D., M.D., or equivalent degree and are nominated
by a preceptor following a formal application procedure. Candidates for
support are evaluated by the Postdoctoral Committee. Postresidency trainees
have completed residency training in General Pediatrics and possess the
knowledge and skills of a Board-certified general pediatrician. Trainees,
therefore, assume increasing clinical responsibilities in the care of
critically ill premature and full term neonates. Trainees also choose
a research laboratory and preceptor from the Program faculty after selection
by the Postresidency Committee. Because of the overlap in research interests
among faculty, the trainees have the opportunity to interact with each
other and with preceptors within a program representing a wide range
of interests in developmental biology, from the most basic to the applied
sciences, enhancing the breadth and depth of their training experience.
Preceptor Research Interests
(Listed in alphabetical order by preceptor)
Ronald L. Ariagno, M.D.
Department of Pediatrics
Division of Neonatal and Developmental Medicine
Research: Infant brain
development, injury and prediction of neurodevelopmental outcome; Sleep,
arousal and circadian development;
Brain homeostasis mechanisms and sudden infant death syndrome (SIDS)
Ann M. Arvin, M.D.
Department of Pediatrics
Division of Infectious Diseases
Research: Host-virus
interactions of herpes viruses in the fetus and newborn.
Ben A. Barres, M.D., Ph.D.
Department of Neurobiology
Research: Development
and function of glia.
Richard D. Bland, M.D.
Department of Pediatrics
Division of Neonatal and Developmental Medicine
Research: Dr Bland's research program (sponsored
by 2 NIH grants) focuses on the pathogenesis and prevention of neonatal
chronic lung disease (bronchopulmonary dysplasia, BPD), with particular
emphasis on understanding mechanisms that contribute to disordered
elastin deposition and associated impairment of alveolar and pulmonary
vascular development that occur in BPD. The research includes studies
of various genes that are thought to regulate the synthesis, assembly
and degradation of elastin in lung tissue obtained from lambs with
chronic lung injury produced by 3-4 weeks of mechanical ventilation
after premature birth. Studies have been done to investigate the impact
of specific therapeutic interventions, including high-frequency mechanical
ventilation, inhaled nitric oxide, retinol, and l-arginine, on the
pathophysiology and histopathology of neonatal chronic lung disease
in preterm lambs. A new element of this project examines the effects
of prolonged, repetitive stretch and associated inflammation on extracellular
matrix proteins, alveolar and vascular development in lungs of newborn
mice.
Helen M. Blau, Ph.D.
Department of Molecular Pharmacology, Program in Gene Therapy
Research: Molecular basis for the genetic regulation
of cell differentiation during development and disease; using muscle
as a model system; gene therapy.
Christopher H. Contag, Ph.D.
Department of Pediatrics
Division of Neonatal and Developmental Medicine
Research: Our laboratory is interested in studying
a variety of biological processes using a noninvasive approach for
monitoring functional changes in living animal models of human development
and disease. These biological processes include infection and treament,
tumor progression and therapy, and normal and pathologic gene expression.
Gerald Crabtree, M.D.
Department of Developmental Biology
Department of Pathology
Research: Regulation in cell proliferation and differentiation.
Genetic regulatory mechanisms in T-lymphocyte activation; lymphoid
development.
Phyllis A. Dennery, M.D.
Department of Pediatrics
Division of Neonatal and Developmental Medicine
Research: Signal transduction during fertilization
and early development.
David Epel, Ph.D.
Department of Biological Sciences
Department of Marine Biology
Research: Our studies of fertilization have contributed
to understanding how developmental programs in eggs are initiated.
Recently we have turned our attention to how development takes place
in the marine environment, especially how embryos resist the effects
of such environmental stresses as ultraviolet radiation, pathogens
and natural and man-made toxins.
Margaret T. Fuller, Ph.D.
Department of Developmental Biology
Department of Genetics
Research: Regulation of Stem Cell Behavior. Cell
Type Specific Transcription Machinery and Tissue Specific Gene Expression.
Regulation of the Meiotic cell cycle. Cell Morphogenesis. Mechanism
of Cytokinesis.
Rona G. Giffard, M.D.
Department of Anesthesia
Research: Anesthetics and ischemic neuronal injury
and astrocyte injury in vitro; primary cell culture; gene expression
and protection from ischemic injury, stress proteins, Hsp-70, Bcl-2,
role of astrocytes in brain injury and protection; neuronal astrocyte
interactions.
Linda C. Giudice, M.D., Ph.D.
Dept. of Gynecology and Obstetrics
Research: Gene expression in human endometrium and
ovary; hormonal regulation of cell and fetal growth; endometrial/placental
interactions.
Jeffrey B. Gould, M.D., Ph.D.
Department of Pediatrics
Division of Neonatal and Developmental Medicine
Research: Looking at the impact of low cesarean section
rates on morbidity and trying to develop a morbidity index that could
be used to assess the quality of perinatal care.
Louis P. Halamek, M.D.
Department of Pediatrics
Division of Neonatal and Developmental Medicine
Research: The use of simulation-based and virtual
reality-based technologies in medical education; human performance
and patient safety.
Dale A. Kaiser, Ph.D.
Department of Biochemistry
Department of Developmental Biology
Research: How are genes regulated to construct a
developmental program? How do signals received from other cells change
the program and coordinate it for multicellular development? The approach
taken by our laboratory group to answer these questions utilizes biochemistry
and genetics; genetics to isolate mutants that have particular defects
in development and biochemistry to determine the molecular basis of
the defects. We study fruiting body development in Myxococcus xanthus,
a social bacterium.
Mark A. Kay, M.D., Ph.D.
Department of Pediatrics
Division of Genetics
Research: The focus is to develop gene transfer technologies
and use them for hepatic gene therapy for the treatment of genetic
and acquired diseases. The general approach is to develop new vector
systems and delivery methods, test them in the appropriate animal models,
and use the most promising approaches in clinical trials. Specifically,
we work on a variety of viral and non-viral vector systems. Our two
major disease models are hemophilia and hepatitis C virus infection.
Seung K. Kim, M.D., Ph.D.
Department of Developmental Biology
Department of Medicine Oncology
Research: We study the genetics of pancreatic islet
cell differentiation using molecular, embryologic and genetic methods
in several model systems, including mice, embryonic stem cells, and
Drosophila. Our work suggests that critical factors required for islet
development are also needed to maintain essential functions of the
mature islet. Our knowledge of genetic and cellular pathways governing
islet formation has allowed us to use stem cell lines to produce functional
islets in vitro.
David M. Kingsley, Ph.D.
Department of Developmental Biology
Research: My laboratory uses a variety of genetic,
cellular, and molecular approaches to study skeletal development in
humans, mice, and stickleback fish. Many of our studies begin with
naturally occuring genetic traits that alter normal skeletal development.
By isolating the genes responsible for these traits, it has been possible
to identify key genetic pathways that control skeletal patterning and
skeletal disease in mice and humans. Similar genetic studies in sticklebacks
are making it possible to determine how new morphological and physiological
traits arise during vertebrate evolution.
Mark A. Krasnow, M.D., Ph.D.
Department of Biochemistry
Research: Genetic, genomic, and cellular analysis
of epithelial morphogenesis in Drosophila and mouse.
Alan M. Krensky, M.D.
Department of Pediatrics
Division of Immunology & Transplantation Biology
Research: Cellular and molecular basis of transplant
and tumor rejection.
David B. Lewis, M.D.
Department of Pediatrics
Division of Immunology and Transplantation Biology
Research: My laboratory has three major research
interests. First, to define cellular and molecular mechanisms that
limit T cell responses to vaccines and pathogens during normal early
postnatal development and in cases of inherited genetic immunodeficiencies.
Second, to determine how exposure to respiratory viral infections,
alters the development of allergen-induced asthma. Third, to determine
how immune responses to cytomegalovirus may influence allograft rejection.
Liqun Luo, Ph.D.
Department of Biological Sciences
Research: Molecular genetics in the fruit fly Drosophila
melanogaster and rodents to study how neurons elaborate their dendrites
and guide their axons, and how neural circuits are formed during development.
Susan McConnell, Ph.D.
Department of Biological Sciences
Research: Exploring the mechanisms by which neurons
in the mammalian central nervous system achieve their normal fates
during development.
Elizabeth D. Mellins, M.D.
Department of Pediartrics
Division of Immunology and Transplantation Biology
Research: Molecular mechanisms and intracellular
pathways of antigen processing and presentation; structure/function
of HLA-DR,-DM, -DO; pathogen evasion of the class II pathway.
Daria Mochly-Rosen, Ph.D.
Department of Molecular Pharmacology
Research: We are studying the mechanism of protein
kinase C-mediated signal transduction in several disease models. Based
on our recent data, we proposed a working hypothesis that activated
PKC isozymes bind to intracellular receptor proteins located at different
subcellular sites, and that these receptors differentially bind specific
PKC isozymes.
Garry P. Nolan, Ph.D.
Department of Molecular Pharmacology
Research: Biochemistry of NF-kB/IkB factors. Nuclear
oncoproteins p50 and Bc1-3; Rel/ankyrin proteins and HIV regulations.
Roeland Nusse, Ph.D.
Department of Developmental Biology
Research: The elucidation of the mechanism of action
of oncogenes in embryogenesis and to extrapolate these findings to
cancerous growth.
Charles G. Prober, M.D.
Department of Pediatrics
Division of Infectious Diseases
Research: The epidemiology and management of perinatal
viral infections.
Marlene Rabinovitch, M.D.
Department of Pediatrics
Division of Cardiology
Research: We investigate mechanisms regulating vascular
cell development to discover novel ways to reverse cardiovascular and
pulmonary disease. Our approaches include targeted gene therapy, transgenic
mouse models and gene arrays. Our focus is on novel vascular elastae
and chymase genes, on the regulation of their transcription factors
which include AML1, on expression of a calcium binding protein, Mts1,
and on a microtubule associated protein regulating mRNA translation.
Matthew P. Scott, Ph.D.
Department of Developmental Biology
Department of Genetics
Research: Genetic regulation of animal development
and human disease. We study homeobox genes, hedgehog/patched signaling
and its links to skin and brain cancer, development of the neural tube
and cerebellum, Wnt signaling, and heart development.
Eric Sibley, M.D.
Department of Pediatrics
Division of Gastroenterology
Research: Transcriptional Regulation of Lactase During
Intestinal Development. The mammalian gastrointestinal tract matures
from a primitive tube into morphologically and functionally distinct
regions during development. The mature small intestine functions in
the digestion and absorption of ingested nutrients.
David K. Stevenson, M.D.
Department of Pediatrics
Division of Neonatal and Developmental Medicine
Research: Heme and bilirubin metabolism in the neonate
utilizing noninvasive technologies combined with developmental biochemistry
approaches.
William S. Talbot, Ph.D.
Department of Developmental Biology
Research: We use genetic and genomic approaches to
investigate the molecular basis of cell fate specification and morphogenesis
in the zebrafish embryo. Other projects include the genetic dissection
of myelination and functional genomics in zebrafish.
Dale T. Umetsu, M.D.
Department of Pediatrics
Division of Immunology
Research: Heterogeneity among human CD4+ T cells
clones; regulation of immune response to heligmosmoides polygyrus by
CD4+ T cell subsets.
Irving L. Weissman, M.D.
Department of Developmental Biology
Research: Developmental biology and function of lymphocytes
using multiple disciplines to study these cells, ranging from molecular
biology to the whole animal.
Requirements
To be appointed to a research training grant, an individual must be
a citizen or a non-citizen national of the United States or must have
been lawfully admitted for permanent residence (i.e., in possession of
a currently valid Alien Registration Receipt Card I-551, or must be in
possession of other legal verification of such status). Individuals on
temporary or student visas are not eligible.
Predotaoral Trainees
Predoctoral trainees must have received a baccalaureate degree by the
beginning date of their NRSA appointment, and must be training at the
post-baccalaureate level in a program leading to the Ph.D. in science
or in an equivalent research doctoral degree program. Health-professional
students who wish to interrupt their studies for a year or more to engage
in full-time research training before completing their professional degrees
are also eligible.
Postdoctoral Trainees
Postdoctoral trainees must have received, as of the beginning date of
the NRSA appointment, a Ph.D., M.D. or comparable doctoral degree from
an accredited domestic or foreign institution. Written certification
by an authorized official of the degree-granting institution that all
degree requirements have been met, prior to the date training is to begin,
is acceptable.
Application Instructions
Stanford University Medical Center (Stanford Health Services) believes
that a residency and fellowship program that is composed of individuals
who are both highly qualified and diverse in terms of culture, gender,
race, ethnicity, background, work and life experiences, skill, and interests
is essential to the postgraduate education of physicians. Because of
its strong belief in the value of diversity, SUMC (The Training Program)
especially encourages applications from African-Americans, Hispanics,
Native Americans, Alaskan Natives and Pacific Islanders, as well as from
others whose backgrounds and experience provide additional dimensions
that will enhance the Developmental and Neonatal Biology Training Program.
Please download the application paperwork.
Brochure 48k Word doc -- 107k PDF
Application 46k Word doc -- 78k
PDF
You may also call, write or e-mail a request for an application:
Division of Neonatal and Developmental Medicine
750 Welch Rd., Suite #315
Palo Alto, CA 94304
(650) 723-5711
(650) 725-8351 (FAX)
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