Endothelial Biology

The Cooke Lab

Our interest is the role of the endothelium in atherosclerosis and in angiogenesis. We are particularly interested in the action of endothelium-derived nitric oxide, and derangements in the nitric oxide synthase pathway that cause vascular disease.

Dysfunctional Endothelial Cell in Dyslipidemia and Atherosclerosis

The research program is vertically integrated from molecule to man, using molecular and cell biological tools, animal models of vascular disease, and vascular imaging and physiologic testing.

Ongoing studies include:

Basic Research:
ADMA: An endogenous inhibitor of NO synthase
Role of NO in Angiogenesis
Role of NO in atherosclerosis
Nicotine is an Agent of Angiogenesis

Clinical Studies:
The NO PAIN study
The Genomics of PAD

Patients, for more information about NO PAIN click here.

Doctors, for more information about NO PAIN click here.

Members of Cooke's Lab

From Left: Vinod Achan, Scott Reiff , Markus Stuehlinger, John Cooke, Chris Heeschen, Sundar Sankaran, Michael Weis, Om Kapoor, Roberta Oka, Andrzej Szuba